促胰液素对犬离体血液灌注心房起搏点活动及收缩性的影响。

Effect of secretin on pacemaker activity and contractility in the isolated blood-perfused atrium of the dog.

Chiba S

Clin Exp Pharmacol Physiol. 1976 Mar-Apr;3(2):167-72. doi: 10.1111/j.1440-1681.1976.tb00601.x.

Abstract

The effects of secretin on inotropic and chronotropic activity were investigated in nine isolated canine atrium preparations which were suspended in a bath and perfused with arterial blood from a carotid artery of a heparinized donor dog. 2. Secretin administered into the cannulated sinus node artery in a dose range of 0-1-10 units produced a dose-related positive inotropic and a biphasic chronotropic effect. 3. The positive chronotropic and inotropic responses to secretin were not suppressed by treatment with alprenolol in doses which blocked responses to noradrenaline. 4. The negative chronotropic response to secretin was not blocked by atropine in doses which blocked the response to acetylcholine. 5. After treatment with glucagon, secretin produced dose-related negative chronotropic and a positive inotropic effects. Thus glucagon may antagonize the positive chronotropic effect of secretin. 6. From these results, it is concluded that secretin has a direct effect on atrial rate and contractility.

摘要

在九个离体犬心房标本中研究了促胰液素对心肌收缩力和心率的影响，这些标本悬浮于浴槽中，并用来自肝素化供体犬颈动脉的动脉血进行灌注。2. 以0.1 - 10单位的剂量范围将促胰液素注入插管的窦房结动脉，产生了剂量相关的正性肌力作用和双相变时作用。3. 用能阻断对去甲肾上腺素反应的剂量的阿普洛尔处理后，对促胰液素的正性变时和正性肌力反应并未受到抑制。4. 用能阻断对乙酰胆碱反应的剂量的阿托品处理后，对促胰液素的负性变时反应并未受到阻断。5. 用胰高血糖素处理后，促胰液素产生了剂量相关的负性变时作用和正性肌力作用。因此，胰高血糖素可能拮抗促胰液素的正性变时作用。6. 从这些结果可以得出结论，促胰液素对心房率和收缩力有直接作用。