Watanabe H
Tohoku J Exp Med. 1978 Feb;124(2):169-76. doi: 10.1620/tjem.124.169.
Results of cytological examination in 120 cases of colon and rectum cancer during the 11-year period ending in 1968 prior to the practical use of fibercolonscope were first studied. At that time, quite favorable results were obtained in cancer of the lower colon and the rectum, but the results were not so satisfactory in cancer of the right side of the colon. After 1969 when the fibercolonscope was introduced into the clinical practice, the range of cytological diagnosis under direct vision was at once expanded to the entire colon. Consequently, diagnosis by the cytological method in 140 cases of cancer of the colon and rectum experienced in 6-year period between 1969 and 1974 revealed favorable results. The results of the cytological diagnosis in cancer of the right sied of the colon, previously not always favorable, improved markedly after the introduction of the cytological method under direct vision through fibercolonscope. When early cancer of the colon and rectum is defined as in early gastric cancer, 40 lesions in 36 patients were detected during the past 19 years. The rate of positive result in cases of early cancer obtained by various diagnostic methods was 83% by the cytological method, 78% by biopsy and 91% by polypectomy. In cases in which both biopsy and cytological method were used, one or both frequently gave positive results. These results would indicate the possibility of correct diagnosis in many cases through the combined use of the cytological method and biopsy, without polypectomy.
对1968年以前11年间在纤维结肠镜实际应用之前的120例结肠癌和直肠癌病例的细胞学检查结果进行了首次研究。当时，乙状结肠和直肠癌取得了相当不错的结果，但右侧结肠癌的结果并不那么令人满意。1969年纤维结肠镜引入临床实践后，直视下细胞学诊断的范围立即扩大到整个结肠。因此，对1969年至1974年6年间经历的140例结肠癌和直肠癌病例进行细胞学诊断，结果令人满意。以前并不总是令人满意的右侧结肠癌的细胞学诊断结果，在通过纤维结肠镜直视下采用细胞学方法后有了明显改善。如果将结肠直肠癌的早期癌症定义与早期胃癌相同，那么在过去19年中检测到36例患者中的40处病变。通过各种诊断方法获得的早期癌症病例的阳性结果率，细胞学方法为83%，活检为78%，息肉切除术为91%。在同时使用活检和细胞学方法的病例中，一种或两种方法经常得出阳性结果。这些结果表明，在不进行息肉切除术的情况下，通过联合使用细胞学方法和活检，在许多病例中有可能做出正确诊断。
