Melville D M, Richman P I, Shepherd N A, Williams C B, Lennard-Jones J E
Imperial Cancer Research Fund, St Mark's Hospital, London.
J Clin Pathol. 1988 Nov;41(11):1180-6. doi: 10.1136/jcp.41.11.1180.
In a prospective study of 100 patients with ulcerative colitis, 82 of whom had extensive colitis, carcinoma and dysplasia were distinguished cytologically from reactive hyperplasia. Six patients had carcinoma complicating colitis and satisfactory samples were obtained from five; the cytological appearances were interpreted as carcinoma in three and as dysplasia in two. Seventy eight patients had not developed carcinoma or dysplasia; the cytological appearances were interpreted as negative for dysplasia in 75 and indefinite for dysplasia in three. In patients who had developed dysplasia the changes seemed to be more widespread on cytological rather than on histological examination. Brush cytology may complement histological assessment in patients with ulcerative colitis who have developed strictures or in whom there is a high suspicion of neoplastic change.
在一项对100例溃疡性结肠炎患者的前瞻性研究中，其中82例患有广泛性结肠炎，通过细胞学方法区分了癌和发育异常与反应性增生。6例患者患有结肠炎合并癌，从5例患者中获取了满意的样本；细胞学表现被解释为3例为癌，2例为发育异常。78例患者未发生癌或发育异常；细胞学表现被解释为75例发育异常为阴性，3例发育异常不明确。在发生发育异常的患者中，细胞学检查显示的变化似乎比组织学检查更为广泛。对于患有狭窄或高度怀疑有肿瘤性改变的溃疡性结肠炎患者，刷检细胞学可补充组织学评估。
