腹裂和脐膨出的发病机制。

The pathogenesis of gastroschisis and omphalocele.

作者信息

deVries P A

出版信息

J Pediatr Surg. 1980 Jun;15(3):245-51. doi: 10.1016/s0022-3468(80)80130-8.

Abstract

Omphalocele and gastroschisis appear, by virtue of their differences in postnatal findings and embryological development, to be different entities. An hypothesis concerning the genesis of gastroschisis is presented which is consistent with observed embryologic sequential change and known teratogenic possibilities. The apparent increase in number of cases of gastroschisis and the frequency of omphalocele warrant further experimental study of their pathogenesis, preferably in primates.

摘要

脐膨出和腹裂，鉴于其出生后表现和胚胎发育的差异，似乎是不同的实体。本文提出了一个关于腹裂发生机制的假说，该假说与观察到的胚胎学顺序变化以及已知的致畸可能性相一致。腹裂病例数的明显增加以及脐膨出的发生率，值得对其发病机制进行进一步的实验研究，最好是在灵长类动物中进行。