Frolov V A, Dvornikov V E, Kazanskaia T A, Pukhlianko V P, Savastenko A E
Biull Eksp Biol Med. 1980 Mar;89(3):358-60.
In chronic alcoholic poisoning the rabbits demonstrate an abrupt decrease in heart left ventricular contractility and a significant noticeable prolongation of the phases of isometric effort and isometric relaxation. The morphologic study of the heart showed marked myocardial hypertrophy and enhanced intramyocardial lypolysis leading to accumulation of acid lipids by the cardiac muscle. It seems likely that these lipids requiring additional oxygen amounts for utilization give rise to relative hypoxia in the myocardium. In conjunction with diastolic inadequacy this can lead to attenuation of the heart contractility and to compensatory development of myocardial hypertrophy.
在慢性酒精中毒时，兔子表现出心脏左心室收缩力突然下降，等长收缩期和等长舒张期明显延长。心脏的形态学研究显示心肌显著肥大，心肌内脂解增强，导致心肌中酸性脂质蓄积。似乎这些需要额外氧量来利用的脂质会引起心肌相对缺氧。再加上舒张功能不全，这会导致心脏收缩力减弱和心肌肥大的代偿性发展。
