Ylikorkala O, Kauppila A, Reinilä M, Tuimala R
Clin Endocrinol (Oxf). 1980 Mar;12(3):261-7. doi: 10.1111/j.1365-2265.1980.tb02709.x.
Levels of unconjugated oestradiol-17 beta (E2) and testosterone (T) and total oestriol (E3) were measured hourly to 6 h after intra-amniotic (i.a.) (100--200 mg) or intravenous (i.v.) (100 mg) injection of dehydroepiandrosterone sulphate (DHEA-S) in a series of twenty-six women with mid-trimester abortion. Amniotic fluid E2 and T levels were elevated significantly 1--6 h after the i.a. injection of DHEA-S, while the E3 level in amniotic fluid did not change. The i.a. administration also induced significant rises in serum E2 and T levels between 1 and 6 h and in the serum E3 level between 2--6 h. The i.v. injection of DHEA-S was accompanied by significantly elevated serum levels of E2 and T, while the E3 concentration remained unchanged. It appears that following maternal i.v. administration or an amniotic fluid injection, DHEA-S is rapidly converted to E2 and T, and these accumulate in both the maternal circulation and the amniotic fluid. E3, however, is formed only after i.a. administration of DHEA-S, and is selectively transported to the maternal blood.
对26例中期流产的女性，在羊膜腔内（ia）注射（100 - 200mg）或静脉注射（iv）（100mg）硫酸脱氢表雄酮（DHEA - S）后，每小时测量一次未结合雌二醇 - 17β（E2）、睾酮（T）和总雌三醇（E3）水平，持续6小时。羊膜腔内注射DHEA - S后1 - 6小时，羊水E2和T水平显著升高，而羊水E3水平未发生变化。羊膜腔内给药还导致1至6小时血清E2和T水平以及2至6小时血清E3水平显著升高。静脉注射DHEA - S后，血清E2和T水平显著升高，而E3浓度保持不变。看来，母体静脉给药或羊膜腔内注射后，DHEA - S迅速转化为E2和T，并在母体循环和羊水中蓄积。然而，E3仅在羊膜腔内注射DHEA - S后形成，并选择性地转运至母体血液中。
