Fuller R W, Snoddy H D
Neuroendocrinology. 1980 Aug;31(2):96-100. doi: 10.1159/000123057.
(+/-)p-Chloroamphetamine hydrochloride, at doses of 1-8 mg/kg i.p. in rats, caused a dose-related increase in serum corticosterone concentration. The increase occurred rapidly, within 30 min, and was over within 4 h. Evidence that the increase was mediated by serotonin release consisted of the following findings: (1) a similar increase did not occur with (+/-)o-chloroamphetamine or (+/-)p-chloro-alpha-methylbenzylamine, analogs of p-chloroamphetamine lacking its ability to deplete serotonin; (2) the increase was prevented by prior treatment with p-chlorophenylalanine, which reduced the brain stores of serotonin available for release by p-chloroamphetamine; (3) the increase was prevented by prior treatment with fluoxetine, an inhibitor of the uptake pump on serotonin neurons, which blocks serotonin release by p-chloroamphetamine, and (4) the increase was mimicked by fenfluramine and norfenfluramine, agents known to release brain serotonin in a manner similar to the action of p-chloroamphetamine. These findings strengthen earlier evidence that brain serotonin neurons have a stimulatory influence on pituitary-adrenocortical function in rats.
（±）对氯苯丙胺盐酸盐，以1 - 8毫克/千克的腹腔注射剂量给予大鼠时，会导致血清皮质酮浓度呈剂量相关的增加。这种增加迅速发生，在30分钟内出现，并在4小时内结束。表明这种增加是由血清素释放介导的证据包括以下发现：（1）（±）邻氯苯丙胺或（±）对氯-α-甲基苄胺不会出现类似的增加，它们是对氯苯丙胺的类似物，但缺乏耗尽血清素的能力；（2）预先用对氯苯丙氨酸处理可防止这种增加，对氯苯丙氨酸会减少大脑中可供对氯苯丙胺释放的血清素储存；（3）预先用氟西汀处理可防止这种增加，氟西汀是血清素神经元摄取泵的抑制剂，可阻止对氯苯丙胺释放血清素；（4）芬氟拉明和去甲芬氟拉明可模拟这种增加，已知这两种药物以类似于对氯苯丙胺的作用方式释放大脑血清素。这些发现强化了早期的证据，即大脑血清素神经元对大鼠垂体 - 肾上腺皮质功能有刺激作用。
