Trulson M E, Jacobs B L
Eur J Pharmacol. 1976 Mar;36(1):149-54. doi: 10.1016/0014-2999(76)90266-1.
Administration of p-chloroamphetamine (PCA) (2.5-10.0 mg/kg) or fenfluramine (FF) (5.0-15.0 mg/kg) to rats induces a behavioral syndrome--consisting of tremor, rigidity, Straub tail, hindlimb abduction, lateral head weaving and reciprocal forepaw treading--which is a reflection of the activity of central serotonin-mediated synapses. The syndrome appears within 3-5 min following i.p. administration of PCA or FF, and the syndrome-inducing effects of PCA and FF are blocked by prior depletion of serotonin with p-chlorophenylalanine. By contrast, the syndrome-inducing effect of 5-methoxy-N,N-dimethyltryptamine (5-M-DMT), which directly stimulates postsynaptic serotonin receptors, is not changed by prior serotonin depletion. Catecholamine depletion with alpha-methyl-p-tyrosine produces essentially no change in the syndrome-inducing effects of PCA, FF or 5-M-DMT. These data indicate that the initial effect of PCA or FF administration is the rapid functional release of stored serotonin.
给大鼠注射对氯苯丙胺（PCA）（2.5 - 10.0毫克/千克）或芬氟拉明（FF）（5.0 - 15.0毫克/千克）会诱发一种行为综合征，该综合征包括震颤、僵硬、施特劳布尾、后肢外展、头部侧向摆动和前爪交替踏地，这反映了中枢5-羟色胺介导的突触的活动。该综合征在腹腔注射PCA或FF后3 - 5分钟内出现，并且PCA和FF诱导综合征的作用可被先用对氯苯丙氨酸耗尽5-羟色胺所阻断。相比之下，直接刺激突触后5-羟色胺受体的5-甲氧基-N，N-二甲基色胺（5-M-DMT）诱导综合征的作用不会因事先耗尽5-羟色胺而改变。用α-甲基对酪氨酸耗尽儿茶酚胺对PCA、FF或5-M-DMT诱导综合征的作用基本上没有影响。这些数据表明，注射PCA或FF的初始效应是储存的5-羟色胺的快速功能性释放。
