Marzoev A I, Rubtsov B V, Klebanov G I, Vladimirov Iu A
Biull Eksp Biol Med. 1980 May;89(5):541-3.
Thyrotoxicosis in rabbits was induced by prolonged intraperitoneal injection of L-thyroxin. The development of thyroxicosis was assoiated with a decreased Ca2+ accumulation rate by sarcoplasmic reticulum (SR) fragments and a lowered Ca2+ dependent ATPase activity. As compared to the analogous parameters in normal animals. Ca2+ accumulation rate and ATPase activity of thyrotoxicosis animals decreased by 60 and 25%, respectively. The changes in the specific parameters of SR were also observed during incubation of normal SR samples in the medium containing thyroxin (10-5 M). The changes seen in SR functioning in thyrotoxicosis animals are likely to be related to structural rearrangements of lipoprotein surroundings of Ca-ATPase.
通过长期腹腔注射L-甲状腺素诱导家兔甲状腺毒症。甲状腺毒症的发展与肌浆网（SR）片段的Ca2+积累速率降低以及Ca2+依赖性ATP酶活性降低有关。与正常动物的类似参数相比，甲状腺毒症动物的Ca2+积累速率和ATP酶活性分别降低了60%和25%。在含有甲状腺素（10-5 M）的培养基中孵育正常SR样品时，也观察到了SR特定参数的变化。甲状腺毒症动物中SR功能的变化可能与Ca-ATP酶脂蛋白周围环境的结构重排有关。
