Hoyer J R
Kidney Int. 1980 Mar;17(3):284-92. doi: 10.1038/ki.1980.34.
Rats immunized with Tamm-Horsfall protein (TH) developed autoantibodies to TH and tubulointerstitial nephritis with granular deposits of IgG, C3, and TH at the base of tubular cells of the thick ascending limb of Henle's loop and selective infiltration of leukocytes around this distal nephron segment. Selective IgG deposition at the base of cells in the tubular segment containing TH and the direct relationships of the amount of immune deposits and the severity of histologic lesions to serum levels of anti-TH antibodies suggest a pathogenetic role for the autoantibodies to TH. The immune deposits in this model of tubulointerstitial nephritis appear to be the consequence of in situ formation of immune complexes. This mechanism involves the diffusion of circulating antibodies to TH across tubular basement membranes and their combination with TH molecules associated with tubular cell surface membranes.
用Tamm-Horsfall蛋白（TH）免疫的大鼠产生了针对TH的自身抗体，并出现了肾小管间质性肾炎，在亨氏袢厚升支的肾小管细胞基部有IgG、C3和TH的颗粒状沉积，且在该远端肾单位段周围有白细胞选择性浸润。在含有TH的肾小管段细胞基部的选择性IgG沉积，以及免疫沉积物的量和组织学病变的严重程度与抗TH抗体血清水平的直接关系，提示针对TH的自身抗体具有致病作用。在这个肾小管间质性肾炎模型中的免疫沉积物似乎是免疫复合物原位形成的结果。这种机制涉及循环抗体向TH穿过肾小管基底膜的扩散，以及它们与与肾小管细胞表面膜相关的TH分子的结合。
