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Scraping fibrosis: UMODulating renal fibrosis.

作者信息

Eddy Allison A

机构信息

Department of Pediatrics, University of Washington, Seattle, Washington, USA.

出版信息

Nat Med. 2011 May;17(5):553-5. doi: 10.1038/nm0511-553.

DOI:10.1038/nm0511-553
PMID:21546974
Abstract
摘要

相似文献

1
Scraping fibrosis: UMODulating renal fibrosis.刮擦纤维化:UMOD调节肾纤维化。
Nat Med. 2011 May;17(5):553-5. doi: 10.1038/nm0511-553.
2
What Does Uromodulin Do?尿调节蛋白有什么作用?
Clin J Am Soc Nephrol. 2020 Dec 31;16(1):150-153. doi: 10.2215/CJN.06390420. Epub 2020 Aug 24.
3
Scraping fibrosis: expressway to the core of fibrosis.刮除纤维化:通向纤维化核心的高速公路。
Nat Med. 2011 May;17(5):552-3. doi: 10.1038/nm0511-552.
4
[Kidney diseases associated with uromodulin (Tamm-Horsfall protein)].[与尿调节蛋白(Tamm-Horsfall蛋白)相关的肾脏疾病]
G Ital Nefrol. 2015;32 Suppl 64.
5
Blood HER2 and Uromodulin as Causal Mediators of CKD.血液 HER2 和尿调蛋白作为 CKD 的因果中介物。
J Am Soc Nephrol. 2018 Apr;29(4):1326-1335. doi: 10.1681/ASN.2017070812. Epub 2018 Mar 6.
6
Hypertension: Uromodulin identified as a potential therapeutic target.高血压:尿调节蛋白被确定为一个潜在的治疗靶点。
Nat Rev Nephrol. 2014 Jan;10(1):2. doi: 10.1038/nrneph.2013.241. Epub 2013 Nov 19.
7
A translational model of chronic kidney disease in swine.猪慢性肾脏病的转化模型。
Am J Physiol Renal Physiol. 2018 Aug 1;315(2):F364-F373. doi: 10.1152/ajprenal.00063.2018. Epub 2018 Apr 25.
8
[Uromodulin - can it be a new marker of kidney damage?].[尿调节蛋白——它会是肾脏损伤的新标志物吗?]
Przegl Lek. 2013;70(11):976-82.
9
The Locus: Insights into the Pathogenesis and Prognosis of Kidney Disease.《病灶:深入了解肾脏疾病的发病机制和预后》
J Am Soc Nephrol. 2018 Mar;29(3):713-726. doi: 10.1681/ASN.2017070716. Epub 2017 Nov 27.
10
Autosomal dominant tubulointerstitial kidney disease caused by uromodulin mutations: seek and you will find.由尿调节蛋白突变引起的常染色体显性遗传性肾小管间质性肾病:寻则得之。
Wien Klin Wochenschr. 2016 Apr;128(7-8):291-4. doi: 10.1007/s00508-015-0948-7. Epub 2016 Jan 25.

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Evaluation of Bcl-2 as a marker for chronic kidney disease prediction in cats.评估Bcl-2作为猫慢性肾病预测标志物的作用。
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From cerebral ischemia towards myocardial, renal, and hepatic ischemia: Exosomal miRNAs as a general concept of intercellular communication in ischemia-reperfusion injury.从脑缺血到心肌、肾和肝缺血:外泌体微小RNA作为缺血再灌注损伤中细胞间通讯的一般概念
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A founder variant is a common cause of hereditary nephropathy in the British population.

本文引用的文献

1
Uromodulin biology and pathophysiology--an update.尿调素的生物学和病理生理学——最新进展。
Kidney Blood Press Res. 2010;33(6):456-75. doi: 10.1159/000321013. Epub 2010 Nov 25.
2
Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension.全基因组关联研究血压极值发现与高血压相关的 UMOD 附近变体。
PLoS Genet. 2010 Oct 28;6(10):e1001177. doi: 10.1371/journal.pgen.1001177.
3
Tamm-Horsfall glycoprotein interacts with renal outer medullary potassium channel ROMK2 and regulates its function.
一个种系变异是英国家族性肾病的常见病因。
J Med Genet. 2023 Apr;60(4):397-405. doi: 10.1136/jmg-2022-108704. Epub 2022 Aug 29.
4
Isozyme-specific comprehensive characterization of transglutaminase-crosslinked substrates in kidney fibrosis.同工酶特异性全面分析肾脏纤维化中转谷氨酰胺酶交联底物
Sci Rep. 2018 May 9;8(1):7306. doi: 10.1038/s41598-018-25674-4.
5
Uromodulin deficiency alters tubular injury and interstitial inflammation but not fibrosis in experimental obstructive nephropathy.尿调节蛋白缺乏改变了实验性梗阻性肾病中的肾小管损伤和间质炎症,但未改变纤维化。
Physiol Rep. 2018 Mar;6(6):e13654. doi: 10.14814/phy2.13654.
6
Common pathway signature in lung and liver fibrosis.肺和肝纤维化中的共同通路特征
Cell Cycle. 2016 Jul 2;15(13):1667-73. doi: 10.1080/15384101.2016.1152435. Epub 2016 Jun 7.
7
Overview of the cellular and molecular basis of kidney fibrosis.肾纤维化的细胞和分子基础概述。
Kidney Int Suppl (2011). 2014 Nov;4(1):2-8. doi: 10.1038/kisup.2014.2.
8
Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression.常见的非编码 UMOD 基因变异通过增加尿调蛋白的表达引起盐敏感性高血压和肾脏损伤。
Nat Med. 2013 Dec;19(12):1655-60. doi: 10.1038/nm.3384. Epub 2013 Nov 3.
9
The immune system and kidney disease: basic concepts and clinical implications.免疫系统与肾脏疾病:基础概念与临床意义。
Nat Rev Immunol. 2013 Oct;13(10):738-53. doi: 10.1038/nri3523. Epub 2013 Sep 16.
10
Uromodulin triggers IL-1β-dependent innate immunity via the NLRP3 inflammasome.尿调素通过 NLRP3 炎性小体触发 IL-1β 依赖性先天免疫。
J Am Soc Nephrol. 2012 Nov;23(11):1783-9. doi: 10.1681/ASN.2012040338. Epub 2012 Sep 20.
Tamm-Horsfall 糖蛋白与肾脏外髓质钾通道 ROMK2 相互作用并调节其功能。
J Biol Chem. 2011 Jan 21;286(3):2224-35. doi: 10.1074/jbc.M110.149880. Epub 2010 Nov 16.
4
Uromodulin and chronic kidney disease.尿调蛋白与慢性肾脏病。
Kidney Blood Press Res. 2010;33(5):393-8. doi: 10.1159/000320681. Epub 2010 Oct 14.
5
Association of variants at UMOD with chronic kidney disease and kidney stones-role of age and comorbid diseases.UMOD 变异与慢性肾脏病和肾结石的关联-年龄和合并症的作用。
PLoS Genet. 2010 Jul 29;6(7):e1001039. doi: 10.1371/journal.pgen.1001039.
6
A transgenic mouse model for uromodulin-associated kidney diseases shows specific tubulo-interstitial damage, urinary concentrating defect and renal failure.一种与尿调素相关的肾脏疾病的转基因小鼠模型表现出特定的肾小管间质性损伤、尿浓缩缺陷和肾衰竭。
Hum Mol Genet. 2010 Aug 1;19(15):2998-3010. doi: 10.1093/hmg/ddq205. Epub 2010 May 14.
7
Uromodulin levels associate with a common UMOD variant and risk for incident CKD.尿调蛋白水平与 UMOD 常见变异体和 CKD 发病风险相关。
J Am Soc Nephrol. 2010 Feb;21(2):337-44. doi: 10.1681/ASN.2009070725. Epub 2009 Dec 3.
8
Uromodulin mutations causing familial juvenile hyperuricaemic nephropathy lead to protein maturation defects and retention in the endoplasmic reticulum.导致家族性青少年高尿酸血症肾病的尿调节蛋白突变会导致蛋白质成熟缺陷并滞留在内质网中。
Hum Mol Genet. 2009 Aug 15;18(16):2963-74. doi: 10.1093/hmg/ddp235. Epub 2009 May 22.
9
Multiple loci associated with indices of renal function and chronic kidney disease.多个与肾功能和慢性肾脏病指标相关的基因座。
Nat Genet. 2009 Jun;41(6):712-7. doi: 10.1038/ng.377. Epub 2009 May 10.
10
Uric acid levels increase risk for new-onset kidney disease.尿酸水平会增加新发肾病的风险。
J Am Soc Nephrol. 2008 Dec;19(12):2251-3. doi: 10.1681/ASN.2008091012. Epub 2008 Oct 29.