Ambrosius H, Schäffner H
Z Gesamte Inn Med. 1980 Jan 15;35(2):38-42.
It is reported on the experimental proofs for the existence of a cooperation of different populations of lymphocytes in man. Regulatory lymphocytes play a part in the regulation of the synthesis of immunoglobulins by polyclonally stimulated B-lymphocytes, in the generation of killer-T-cells and in the regulation of the DNA-synthesis by mitogenically stimulated T- and B-cells. Typical helper- and suppressor-effects may be proved. Disturbances of lymphocytic interactions may be a cause for the development of immune deficiency diseases. It is very probable that also in several chronic infections a dysfunction of regulatory T-lymphocytes is present.
据报道，关于人类不同淋巴细胞群体之间存在合作的实验证据。调节性淋巴细胞在多克隆刺激的B淋巴细胞免疫球蛋白合成调节、杀伤性T细胞的产生以及有丝分裂原刺激的T细胞和B细胞DNA合成调节中发挥作用。典型的辅助和抑制作用可以得到证实。淋巴细胞相互作用的紊乱可能是免疫缺陷疾病发展的一个原因。很可能在一些慢性感染中也存在调节性T淋巴细胞功能障碍。
