Suetsugu M, Mehraein P
Acta Neuropathol. 1980;50(3):207-10. doi: 10.1007/BF00688755.
The number of spines along the apical dendrites of the pyramidal neurons in the hippocampal and cingulate gyri were counted on Golgi preparations of the brains of seven cases of Down's syndrome; they did not show neuropathological senile changes. The number of spines in the middle and distal segments of the apical dendrites of Down's syndrome group were significantly fewer than in those of the control group. The number of spines in aged noncharacteristic mentally retarded cases were not decreaed compared with the controls. The diminution of spines in Down's syndrome is considered to be rather specific in this condition and is not a common finding in other types of mental retardation. It might also be one of the early changes of dendritic degeneration related to senile plaque formation.
在七例唐氏综合征患者大脑的高尔基染色标本上，对海马回和扣带回中锥体神经元顶树突上的棘突数量进行了计数；这些标本未显示神经病理学上的老年变化。唐氏综合征组顶树突中段和远端的棘突数量明显少于对照组。与对照组相比，老年非特异性智力迟钝病例的棘突数量并未减少。唐氏综合征中棘突数量的减少在这种情况下被认为是相当特异的，并非其他类型智力迟钝中的常见表现。它也可能是与老年斑形成相关的树突退化的早期变化之一。
