哌拉西林治疗伴有铜绿假单胞菌耐药获得及临床复发情况的临床试验
Clinical trial of piperacillin with acquisition of resistance by Pseudomonas and clinical relapse.
作者信息
Simon G L, Snydman D R, Tally F P, Gorbach S L
出版信息
Antimicrob Agents Chemother. 1980 Jul;18(1):167-70. doi: 10.1128/AAC.18.1.167.
Abstract
A total of 20 serious infections were treated with piperacillin. These infections included bacteremias (5), pneumonias (5), urinary tract infections (5), soft tissue infections (3), septic arthritis (1), and osteomyelitis (1). The most common bacterial pathogen was Pseudomonas aeruginosa, accounting for eight infections. The clinical and bacteriological response rates were 75 and 70%, respectively. Four of the five patients who failed to respond to piperacillin therapy were infected with Pseudomonas. In two patients with Pseudomonas infections clinical relapse was accompanied by the development of piperacillin-resistant P. aeruginosa. The findings suggest that the use of piperacillin as a single agent for the treatment of serious gram-negative infections may be ill-advised, especially if P. aeruginosa is the offending pathogen.
摘要
共有20例严重感染患者接受了哌拉西林治疗。这些感染包括菌血症（5例）、肺炎（5例）、尿路感染（5例）、软组织感染（3例）、化脓性关节炎（1例）和骨髓炎（1例）。最常见的细菌病原体是铜绿假单胞菌，占8例感染。临床和细菌学反应率分别为75%和70%。5例对哌拉西林治疗无反应的患者中有4例感染了铜绿假单胞菌。在2例铜绿假单胞菌感染患者中，临床复发伴随着耐哌拉西林铜绿假单胞菌的出现。这些发现表明，将哌拉西林作为单一药物用于治疗严重革兰氏阴性感染可能是不明智的，尤其是如果铜绿假单胞菌是致病病原体。
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