临床材料中铜绿假单胞菌对羧苄青霉素的耐药性
Carbenicillin resistance in Pseudomonas aeruginosa from clinical material.
作者信息
Darrell J H, Waterworth P M
出版信息
Br Med J. 1969 Jul 19;3(5663):141-3. doi: 10.1136/bmj.3.5663.141.
Abstract
Strains of Pseudomonas aeruginosa resistant to 256 mug. per ml. or more of carbenicillin (Pyopen) were isolated from 17 patients over a period of three months. The infections were not solely due to cross-infection. Low dosage and attempted eradication of the organism from inaccessible sites, such as the bronchi or skin surfaces, by using systemic treatment are two possible causes. Restraint in treating infections of doubtful importance and the use of local applications to appropriate sites with or without systemic treatment is suggested.
摘要
在三个月的时间里，从17名患者身上分离出了对每毫升256微克或更高剂量羧苄青霉素（羧苄西林）耐药的铜绿假单胞菌菌株。这些感染并非完全由交叉感染引起。低剂量以及通过全身治疗试图从难以到达的部位（如支气管或皮肤表面）根除该病菌是两个可能的原因。建议在治疗重要性存疑的感染时保持克制，并在有或没有全身治疗的情况下对适当部位进行局部用药。
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