Gottlob R, Knapp G, Porschinski K, Saghir F
Rofo. 1980 Feb;132(2):204-7. doi: 10.1055/s-2008-1056551.
The damaging action on vascular endothelia of meglumin iothalamate and of meglumin ioxitalamate was tested on the rat aorta. Ioxitalamate was significantly better tolerated than iothalamate. The octanol-water-partition coefficient of various contrast media was evaluated by assessing the iodine content of the octanol phase after mixing. The coefficients found were about 100 fold lower than the coefficients computed by Levitan and Rapoport. The significance of the octanol-water-partition coefficient for endothelial injuries caused by contrast media is disputed.
在大鼠主动脉上测试了碘他拉葡胺和碘克沙葡胺对血管内皮的损伤作用。碘克沙葡胺的耐受性明显优于碘他拉葡胺。通过评估混合后辛醇相中的碘含量来测定各种造影剂的辛醇 - 水分配系数。所得到的系数比Levitan和Rapoport计算出的系数低约100倍。造影剂引起的内皮损伤与辛醇 - 水分配系数的相关性存在争议。
