对携带P388或L1210白血病的小鼠口服蒽环类药物7-氧甲基诺加罗（7-OMEN）的活性。
Activity of the anthracycline agent, 7-con-O-methylnogarol (7-OMEN), administered orally to mice bearing P388 or L1210 leukemia.
作者信息
McGovren J P
出版信息
Cancer Treat Rep. 1980 Apr-May;64(4-5):727-9.
PMID:6448690
Abstract
The magnitudes of the therapeutic and toxic responses observed when 7-con-O-methylnogarol (7-OMEN) was administered orally to mice inoculated ip or iv with P388 of L1210 leukemia were essentially equivalent to those seen after ip administration of the drug, indicating a significant degree of gastrointestinal absorption.
摘要
当给腹腔注射或静脉注射L1210白血病P388的小鼠口服7-氧代-O-甲基诺加罗尔（7-OMEN）时，观察到的治疗反应和毒性反应的程度与腹腔注射该药物后观察到的基本相当，这表明胃肠道有显著程度的吸收。
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