Chen S E, Tse C S, Bernstein I L, Archer D
Int Arch Allergy Appl Immunol. 1980;63(4):470-2. doi: 10.1159/000232665.
Effects of staphylococcal enterotoxin A (SEA) on the mouse homocytotropic antibody (HCA) system were studied. Groups of BDF mice received 10 micrograms SEA either orally or intraperitoneally at 0, 24, 48 h before or after immunization with 100 micrograms ovalbumin in 1 mg A1(OH)3 gel. Primary and secondary HCA responses were determined by 48-hour passive cutaneous anaphylactic reactions in genetically hairless mice. It was found that effects of SEA on HCA responses were dependent on the time and route of SEA administration. In general, early administration (48 h before immunization) of SEA showed suppression, while later administration (either 24 h before or after immunization) of SEA demonstrated enhancement. A further delay of SEA administration (48 h after immunization) exerted suppressive effects except when it was given intraperitoneally in the anamnestic HCA experiments. The mouse HCA system proved to be a suitable in vivo correlate of in vitro plaque-forming cell responses modulated by SEA.
研究了葡萄球菌肠毒素A（SEA）对小鼠亲同种细胞抗体（HCA）系统的影响。将BDF小鼠分组，在以1mg氢氧化铝凝胶中的100μg卵清蛋白免疫前或后0、24、48小时，经口或腹腔注射给予10μg SEA。通过对基因无毛小鼠进行48小时被动皮肤过敏反应来测定初次和二次HCA反应。发现SEA对HCA反应的影响取决于SEA给药的时间和途径。一般来说，SEA早期给药（免疫前48小时）表现为抑制作用，而后期给药（免疫前或后24小时）则表现为增强作用。SEA给药的进一步延迟（免疫后48小时）除了在回忆性HCA实验中腹腔注射时外，均产生抑制作用。小鼠HCA系统被证明是SEA调节的体外空斑形成细胞反应的合适体内相关指标。
