McGrae J D, Zelickson A S
Arch Dermatol. 1980 Nov;116(11):1262-5.
Localized brown to blue-black discoloration of the skin occurred in three patients receiving long-term minocycline hydrochloride therapy. Abundant perivascular pigmented material was present at all levels of the dermis below the upper papillary portion. Histochemical studies demonstrated reactivity with the Prussian blue stain and the Fontana-Masson silver technique. The granules were brightly refractile by dark-field illumination. Ultrastructurally, there were membrane-bound dense intracellular inclusions differing from melanin and iron but identical to those known to occur in the thyroid glands of minocycline-primed laboratory animals. The abnormal pigment most likely represents a metabolic derivative of minocycline.
三名接受长期盐酸米诺环素治疗的患者出现了皮肤局部由棕色至蓝黑色的变色。在真皮乳头层上部以下的各层均有丰富的血管周围色素沉着物质。组织化学研究表明，该物质对普鲁士蓝染色和丰塔纳-马森银染色技术有反应。通过暗视野照明，这些颗粒具有明亮的折光性。超微结构显示，存在膜结合的致密细胞内包涵体，其不同于黑色素和铁，但与在预先用米诺环素处理的实验动物甲状腺中发现的包涵体相同。这种异常色素很可能代表米诺环素的一种代谢衍生物。
