Fenske N A, Millns J L, Greer K E
JAMA. 1980 Sep 5;244(10):1103-6.
In four cases of minocycline hydrochloride-induced cutaneous pigmentation, blue-gray discoloration in sites of cutaneous inflammation was seen in all cases. An additional finding of generalized, brown hyperpigmentation with accentuation in sun-exposed areas was noted in one. Although all of the patients had used relatively high doses of medication, the variable duration of therapy before pigmentary changes and dearth of similar reports suggest an idiosyncratic response to this commonly used medication. Histochemical stains and electron microscopic studies suggest hemosiderin or a pigment with similar staining properties; a minocycline degradation product, however, cannot be discounted.
在4例盐酸米诺环素引起的皮肤色素沉着病例中，所有病例的皮肤炎症部位均出现蓝灰色色素沉着。其中1例还发现有全身性褐色色素沉着，在暴露于阳光下的部位更为明显。尽管所有患者均使用了相对高剂量的药物，但色素改变前的治疗时间长短不一，且缺乏类似报告，提示对这种常用药物存在特异反应。组织化学染色和电子显微镜研究提示含铁血黄素或具有类似染色特性的色素；然而，米诺环素降解产物也不能排除。
