Minocycline and generalized cutaneous pigmentation.

The recent literature contains sporadic mention of localized pigmentary accumulations in skin, bones, teeth, and thyroid tissue, presumably related to the use of systemic minocycline hydrochloride. It is our purpose to report the occurrence of generalized, cutaneous, dark blue-gray hyperpigmentation that developed in a woman while she was being treated with minocycline (Minocin) for acne vulgaris. We believe this pigmentary change to be minocycline-induced.