Nicolas J P, Marcoullis G
C R Seances Soc Biol Fil. 1980;174(4):548-63.
The present paper outlines the classical concepts of transport and absorption of vitamin B12 and discusses findings which provide new insight into the important role of pancreatic enzymes in the absorption of the vitamin B12. In vivo experiments with healthy subjects and patients with exocrine pancreatic insufficiency demonstrate that the pancreatic enzymes do not activate "the precursor" intrinsic factor molecule but solely dissociate vitamin from the inactive R type proteins with a consequent coupling to the biologically active intrinsic factor.
本文概述了维生素B12转运和吸收的经典概念，并讨论了一些研究结果，这些结果为胰腺酶在维生素B12吸收中的重要作用提供了新的见解。对健康受试者和外分泌性胰腺功能不全患者进行的体内实验表明，胰腺酶不会激活“前体”内因子分子，而只是将维生素从无活性的R型蛋白中解离出来，随后与生物活性内因子结合。
