Von Der Lippe G, Andersen K J, Schjönsby H
Scand J Gastroenterol. 1976;11(7):689-95.
The mean absorption of vitamin B12 (Schilling test) was 13.1 +/- 1.0 (% +/- S.E.M.) in 21 patients with chronic pancreatic insufficiency and 17.6 +/- 1.4 in 13 control patients (p less than 0.01). There was no correlation between pancreatic bicarbonate production after secretion stimulation and vitamin B12 absorption in the patient group (r = 0.117). Human duodenal juice reduced the uptake of 57CoB12-rat intrinsic factor (IF) by perfused rat small intestinal segments in vivo (p less than 0.01) as well as the uptake of 57CoB12-human IF by purified guinea-pig intestinal brush borders in vitro (p less than 0.01). The results confirm reduced absorption of vitamin B12 in chronic pancreatic insufficiency, but the mechanism remains uncertain.
21例慢性胰腺功能不全患者维生素B12的平均吸收量（希林试验）为13.1±1.0（%±标准误），13例对照患者为17.6±1.4（p<0.01）。患者组分泌刺激后胰腺碳酸氢盐生成量与维生素B12吸收之间无相关性（r=0.117）。人十二指肠液在体内降低了经灌注的大鼠小肠段对57CoB12-大鼠内因子（IF）的摄取（p<0.01），在体外也降低了纯化的豚鼠肠刷状缘对57CoB12-人IF的摄取（p<0.01）。结果证实慢性胰腺功能不全时维生素B12吸收减少，但机制仍不确定。
