Fabry L
C R Seances Soc Biol Fil. 1980;174(5):889-92.
The micronucleus test has been used to study the mutagenic activity of chromium derivatives and to examine the relationship between their carcinogenic properties and their ability to induce chromosomal damage. It has been found that potassium dichromate is a potent mutagen increasing, for instance, the rate of micro-nucleated erythrocytes while calcium chromate and chromic nitrate are ineffective. From our observations and the data on carcinogenicity, it can be concluded that the micronucleus test cannot be used to predict the carcinogenic properties of chromium derivatives.
微核试验已被用于研究铬衍生物的诱变活性，并检验其致癌特性与诱导染色体损伤能力之间的关系。已发现重铬酸钾是一种强效诱变剂，例如可增加微核化红细胞的比例，而铬酸钙和硝酸铬则无此作用。根据我们的观察结果和致癌性数据，可以得出结论：微核试验不能用于预测铬衍生物的致癌特性。
