Przybojewska B, Barański B, Spiechowicz E, Dziubałtowska E, Szymczak W
Department of Occupational Carcinogenesis, Institute of Occupational Medicine, Lódź, Poland.
Acta Pol Pharm. 1994;51(1):89-93.
Potential carcinogenic activity of alpha-aescin and phenbendasole made by "Polfa" (Poland) as well as phenbendasole produced by "Hoechst" (Germany) was studied using Salmonella/microsome test, DNA repair test and micronucleus assay. None of tested preparations were mutagenic or genotoxic what suggest that none of them possess potential carcinogenic activity. Besides, it was established that alpha-aescin exhibits strong and phenbendasol weak acute systemic toxicity for mice. Alpha-aescin and phenbendasole produced in Poland have been found to be toxic for bone marrow cells of mice but only when administered at a high dose of 80% LD50.
使用沙门氏菌/微粒体试验、DNA修复试验和微核试验，对波兰“Polfa”公司生产的α-七叶皂苷和苯硫哒唑以及德国“Hoechst”公司生产的苯硫哒唑的潜在致癌活性进行了研究。所测试的制剂均无致突变性或基因毒性，这表明它们均不具有潜在致癌活性。此外，已确定α-七叶皂苷对小鼠具有强烈的急性全身毒性，而苯硫哒唑的毒性较弱。已发现波兰生产的α-七叶皂苷和苯硫哒唑对小鼠骨髓细胞有毒性，但仅在以80% LD50的高剂量给药时才会出现这种情况。
