Tamayo L, Ruiz-Maldonado R
Dermatologica. 1980;161(5):305-14. doi: 10.1159/000250382.
8 children with lamellar ichthyosis, 1 with epidermolytic hyperkeratosis and 5 with symmetrical progressive erythrokeratoderma were treated with a new aromatic retinoid (Ro 10-9359). Clinical improvement was dramatic. The children acquired an appearance never obtained before with other managements. The treatment had to be maintained to prevent recurrence. The tolerance to the drug was good. The side-effects were minimal and tended to disappear after several months of treatment. Our results suggest that because of its efficacy, good tolerance and easy administration, the oral retinoid Ro 10-9359 is at present the treatment of choice for the great ichthyotic disorders of children.
8名板层状鱼鳞病患儿、1名表皮松解性角化过度患儿和5名对称性进行性红斑角化病患儿接受了一种新型芳香维甲酸（Ro 10 - 9359）治疗。临床改善显著。这些患儿获得了以往其他治疗方法从未达到的外观。必须持续进行治疗以防止复发。对该药物的耐受性良好。副作用极小，且在治疗数月后往往会消失。我们的结果表明，由于其疗效、良好的耐受性和易于给药，口服维甲酸Ro 10 - 9359目前是儿童严重鱼鳞病的首选治疗方法。
