Frenk E
Dermatologica. 1981;162(2):91-103.
3 patients with lamellar ichthyosis have been treated orally with the aromatic retinoid Ro 10-9359 for periods of more than 2 years. This treatment resulted in a satisfactory improvement in the skin condition without any major side-effects. A light- and electron-microscopic study showed a marked decrease in the thickness of the lamellar stratum corneum without giving any clues concerning the mechanism of the therapeutic effect of this drug.
3例板层状鱼鳞病患者口服芳香维甲酸Ro 10-9359进行治疗，疗程超过2年。该治疗使皮肤状况得到了令人满意的改善，且无任何严重副作用。光镜和电镜研究显示板层角质层厚度显著降低，但未提供有关该药物治疗效果机制的任何线索。
