Mutton D E, Lea J
Dev Med Child Neurol. 1980 Oct;22(5):588-94. doi: 10.1111/j.1469-8749.1980.tb04372.x.
Among 88 children with speech and language problems from whom chromosome results were obtained, four were identified with a chromosome anomaly. Three had sex chromosome aneuploidy and had developmental problems, particularly with articulation. The fourth child had low-grade trisomy 21 in blood, with minimal signs of Down's syndrome but with bilateral conductive hearing loss. It is suggested that delay in speech development is one facet of the developmental problems that may be significant in later behavioural problems in adolescent and adult males with X and Y aneuploidy.
在88名获得染色体检测结果的言语和语言问题儿童中，有4名被确定存在染色体异常。其中3名患有性染色体非整倍体，有发育问题，尤其是发音方面。第四名儿童血液中存在低水平的21三体，仅有轻微的唐氏综合征体征，但患有双侧传导性听力损失。研究表明，言语发育迟缓是发育问题的一个方面，这对于患有X和Y染色体非整倍体的青春期及成年男性日后的行为问题可能具有重要意义。
