Spokes E G, Garrett N J, Rossor M N, Iversen L L
J Neurol Sci. 1980 Dec;48(3):303-13. doi: 10.1016/0022-510x(80)90103-3.
Gamma-aminobutyric acid (GABA) concentrations were measured in 10 regions of post-mortem brain from control, psychotic and choreic subjects; glutamate decarboxylase (GAD) activities were estimated in substantia nigra. In agreement with earlier observations, agonal status profoundly affected GAD measurements in the substantia nigra but had no effect on GABA levels in any brain region. Although GAD and GABA levels were significantly correlated in nigral tissue from sudden death control and psychotic cases, the association was lost in patients dying slowly. In Huntington's chorea significant reduction in GABA content were observed in the nucleus accumbens, lateral pallidum, subthalamic nucleus, substantia nigra and ventrolateral thalamic nucleus. In psychotic patients there were significant decreases in GABA concentrations in the amygdala and nucleus accumbens. Division of the psychotic group into schizophrenia and schizophrenia-like categories and into early-onset and later-onset cases revealed that GABA levels in the amygdala were diminished in all 4 psychotic subgroups, whereas in the nucleus accumbens the deficit was confined to cases of early-onset schizophrenia.
在对照组、精神病患者组和舞蹈症患者组的10个大脑尸检区域中测量了γ-氨基丁酸（GABA）浓度；在黑质中估计了谷氨酸脱羧酶（GAD）活性。与早期观察结果一致，濒死状态对黑质中的GAD测量有显著影响，但对任何脑区的GABA水平均无影响。虽然在猝死对照组和精神病患者的黑质组织中GAD和GABA水平显著相关，但在缓慢死亡的患者中这种关联消失了。在亨廷顿舞蹈症中，伏隔核、外侧苍白球、丘脑底核、黑质和丘脑腹外侧核中的GABA含量显著降低。在精神病患者中，杏仁核和伏隔核中的GABA浓度显著降低。将精神病患者组分为精神分裂症和类精神分裂症类别以及早发和晚发病例后发现，在所有4个精神病亚组中杏仁核中的GABA水平均降低，而在伏隔核中，缺陷仅限于早发性精神分裂症病例。
