膦甲酸钠三钠抑制土拨鼠肝炎病毒相关DNA聚合酶。

Trisodium phosphonoformate inhibits woodchuck hepatitis virus associated DNA polymerase.

作者信息

Nordenfelt E, Werner B

出版信息

Acta Pathol Microbiol Scand B. 1980 Jun;88(3):183-4. doi: 10.1111/j.1699-0463.1980.tb02625.x.

DOI:10.1111/j.1699-0463.1980.tb02625.x

Abstract

Recently a new virus has been described which infects woodchucks, Marmota monax. This virus, named woodchuck hepatitis virus (WHV) is closely related to human hepatitis virus (HBV). The virions have the same principal antigenic system involving surface and core determinants and a serological relationship has been found. WHV has also a DNA polymerase associated with the core. It has previously been reported that trisodium phosphonoformate (PFA) but not phosphonoacetic acid (PAA) inhibits DNA polymerase associated with HBV. This investigation shows the same type of inhibition pattern by PFA and PAA on WHV DNA polymerase.

摘要

最近，一种感染土拨鼠（Marmota monax）的新型病毒被发现。这种病毒被命名为土拨鼠肝炎病毒（WHV），与人类肝炎病毒（HBV）密切相关。病毒粒子具有相同的主要抗原系统，包括表面和核心决定簇，并且已发现它们之间存在血清学关系。WHV还具有与核心相关的DNA聚合酶。此前有报道称，膦甲酸钠（PFA）可抑制与HBV相关的DNA聚合酶，而膦乙酸（PAA）则不能。本研究表明，PFA和PAA对WHV DNA聚合酶具有相同类型的抑制模式。