土拨鼠肝炎病毒与人乙型肝炎病毒内源性DNA聚合酶特性的比较。
Comparison of properties of woodchuck hepatitis virus and human hepatitis B virus endogenous DNA polymerases.
作者信息
Hantz O, Ooka T, Vitvitski L, Pichoud C, Trepo C
出版信息
Antimicrob Agents Chemother. 1984 Feb;25(2):242-6. doi: 10.1128/AAC.25.2.242.
Abstract
The principal properties of the DNA polymerases of woodchuck hepatitis virus and human hepatitis B virus were compared. The enzymes of both viruses exhibited optimal activities in the same range of pH, ionic strength, and MgCl2 concentration. Like human hepatitis B virus DNA polymerase, the woodchuck hepatitis virus DNA polymerase was strongly inhibited by phosphonoformic acid but not by phosphonoacetic acid and aphidicolin. Similar inhibition patterns for both enzymes were observed with arabinofuranosyl nucleotides (9-beta-D-arabinofuranosyladenine-5'-triphosphate, 1-beta-D-arabinofuranosylcytosine-5'-triphosphate, 1-beta-D-arabinofuranosylthymine-5'-triphosphate) and dideoxythymidine triphosphate, whereas no effect was obtained with corresponding nucleosides. The therapeutic significance of these results and the relevance of the woodchuck as an experimental animal model for the study of human hepatitis B virus infections are discussed.
摘要
对土拨鼠肝炎病毒和人类乙型肝炎病毒的DNA聚合酶的主要特性进行了比较。两种病毒的酶在相同的pH、离子强度和MgCl2浓度范围内表现出最佳活性。与人类乙型肝炎病毒DNA聚合酶一样，土拨鼠肝炎病毒DNA聚合酶受到膦甲酸的强烈抑制，但不受膦乙酸和阿非迪霉素的抑制。用阿拉伯呋喃糖核苷酸（9-β-D-阿拉伯呋喃糖基腺嘌呤-5'-三磷酸、1-β-D-阿拉伯呋喃糖基胞嘧啶-5'-三磷酸、1-β-D-阿拉伯呋喃糖基胸腺嘧啶-5'-三磷酸）和双脱氧胸苷三磷酸观察到两种酶的类似抑制模式，而相应的核苷则没有效果。讨论了这些结果的治疗意义以及土拨鼠作为研究人类乙型肝炎病毒感染的实验动物模型的相关性。
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