Batra J K, Raj H G, Venkitasubramanian T A
Experientia. 1980 Nov 15;36(11):1311. doi: 10.1007/BF01969607.
Systemic action of nicotinamide significantly alters the activities of hepatic drug metabolizing enzymes. Male rats injected with nicotinamide have reduced levels of cytochrome P450, demethylases and aniline hydroxylase. The changes appear to be sex-dependent since in the case of female rats activities of p-nitroanisole-o-demethylase and aniline hydroxylase are enhanced whereas cytochrome P450 content remains unaltered.
烟酰胺的全身作用显著改变肝脏药物代谢酶的活性。注射烟酰胺的雄性大鼠细胞色素P450、脱甲基酶和苯胺羟化酶水平降低。这些变化似乎具有性别依赖性，因为在雌性大鼠中，对硝基苯甲醚邻脱甲基酶和苯胺羟化酶的活性增强，而细胞色素P450含量保持不变。
