Chen H F, Nakabayashi M, Satoh K, Sakamoto S
Acta Obstet Gynecol Scand. 1980;59(6):499-504. doi: 10.3109/00016348009155439.
Serial determinations of urinary plasmin level by radiocaseinolytic assay were performed in 40 healthy women and 29 patients with various types of toxemia throughout pregnancy, labor and the puerperium. The results indicate that: 1. The urinary plasmin level in normal pregnancy increased significantly from the third trimester to the early puerperium. 2. In mild pre-eclampsia, a significant rise in urinary plasmin level from 26 weeks of gestation to the 4th day post-partum. 3. In severe pre-eclampsia, a progressive decrease in late pregnancy was found. After delivery, in the early puerperium, the urinary plasmin level of the patients with a rapid clinical was significantly higher than that of the patients with the sequelae of toxemia. Our study showed that serial assays of urinary plasmin activity can provide a reliable and sensitive index of severity, progression and natural history of toxemia of pregnancy.
通过放射性酪蛋白溶解测定法对40名健康女性和29名患有各种类型毒血症的患者在整个孕期、分娩期及产褥期进行尿纤溶酶水平的系列测定。结果表明：1. 正常妊娠时尿纤溶酶水平从妊娠晚期至产褥早期显著升高。2. 在轻度先兆子痫中，从妊娠26周直至产后第4天尿纤溶酶水平显著升高。3. 在重度先兆子痫中，妊娠晚期发现其逐渐下降。分娩后，在产褥早期，临床恢复快的患者尿纤溶酶水平显著高于有毒血症后遗症的患者。我们的研究表明，尿纤溶酶活性的系列测定可为妊娠毒血症的严重程度、进展及自然病程提供可靠且敏感的指标。
