Manford M L, Roberts G J
Anaesthesia. 1980 Dec;35(12):1157-68. doi: 10.1111/j.1365-2044.1980.tb05072.x.
A trial was undertaken to assess the suitability of oxygen/nitrous oxide sedation (relative analgesia) for dental treatment in unmanageable handicapped young patients. Fifty patients with chronological ages 5-22 years and mental ages 1 1/2-14 years participated in the double blind trial to see if premedication with diazepam 0.2 mg/kg would be a useful adjunct. After the trial, previous dental histories and behaviour at regular recall visits over the next 12-18 months were studied. Seventeen of 19 patients previously treated with general anaesthesia and 27 of 31 formerly untreated patients accepted treatment in the trial; of the 50 patients, 33 are continuing treatment with oxygen/nitrous oxide sedation, seven need general anaesthesia and 10 have moved from the district. It appears that the use of diazepam premedication improves patient demeanour and operating conditions although this improved effect is not carried over to recall visits. The results obtained indicate that routine dental procedures can be safely carried out by an experienced operator-sedationist in young handicapped patients using oxygen/nitrous oxide sedation. The frequency with which potentially hazardous techniques need to be used can be reduced, as can hospital admissions.
开展了一项试验，以评估氧气/一氧化二氮镇静（相对镇痛）用于难以处理的残疾年轻患者牙科治疗的适用性。50名实际年龄在5至22岁、心理年龄在1.5至14岁的患者参与了这项双盲试验，以观察0.2毫克/千克的地西泮预处理是否会是一种有用的辅助手段。试验结束后，研究了患者先前的牙科病史以及在接下来12至18个月定期复诊时的行为。19名先前接受过全身麻醉的患者中有17名，31名先前未接受过治疗的患者中有27名在试验中接受了治疗；在这50名患者中，33名继续采用氧气/一氧化二氮镇静进行治疗，7名需要全身麻醉，10名已搬离该地区。似乎地西泮预处理的使用改善了患者的行为表现和手术条件，尽管这种改善效果在复诊时并未持续。所获得的结果表明，经验丰富的操作人员-镇静师使用氧气/一氧化二氮镇静可为残疾年轻患者安全地实施常规牙科手术。可以减少潜在危险技术的使用频率，也可以减少住院次数。
