Seĭbil' V B, Efimova V F, Troshina L D, Ershova G A
Vopr Virusol. 1978 Jan-Feb(1):43-7.
Examinations of children in the Moscow region in 1972 revealed low values of the herd immunity to poliomyolitis. This was suggested to be due to improper organization of vaccination of children. The regional health authorities took special measures for better organization of vaccination. The examinations two years later, in 1974, showed nearly 90% of children between the ages of 1 and 6 years to have antibody to all three types of poliomyelitis virus. The geometric mean antibody titre increased. In children of 10--14 years the heard immunity values did not differ significantly from those found in 1972. It is concluded that proper vaccination gives sufficiently intensive immunity nearly in 90% of children. It was found that in children vaccinated 10--12 times the herd immunity persists without significant changes for 3 years after the last vaccine feeding; at 4 years, however, some values of the herd immunity, particularly to poliomyelitis virus type III, were significantly lower than the original values. It is suggested that it is likely to be expedient to revaccinate 4-grade schoolchildren and to reduce the total number of vaccine feedings during the first 4 years of life.
1972年对莫斯科地区儿童的检查发现，脊髓灰质炎的群体免疫力值较低。这被认为是由于儿童疫苗接种组织不当所致。地区卫生当局采取了特别措施，以更好地组织疫苗接种。两年后的1974年检查显示，1至6岁的儿童中近90%对所有三种脊髓灰质炎病毒都有抗体。几何平均抗体滴度有所上升。10至14岁儿童的群体免疫值与1972年的检查结果相比没有显著差异。得出的结论是，适当的疫苗接种能使近90%的儿童获得足够强的免疫力。研究发现，接种10至12次疫苗的儿童，群体免疫力在最后一次喂服疫苗后3年内持续存在且无显著变化；然而，4年后，一些群体免疫值，尤其是对III型脊髓灰质炎病毒的免疫值，明显低于初始值。建议对四年级学童进行再次接种，并减少生命最初4年内的疫苗喂服总数，这可能是适宜的。
