Scherzer W, Kraft D, Cerni C, Scheiner O, Lackner J, Spitzy K H
Derm Beruf Umwelt. 1980;28(6):175-81.
538 patients, admitted to the hospitals participating in this study for a variety of indications for antibacterial therapy, were treated by the ampicillin-analogue Epicillin. 42 patients (7.8%) who developed exanthem underwent detailed clinical and immunological investigation. Exanthems were scored according to the form of application and doses of Epicillin as well as to the morphology and time of onset of the exanthem. A variety of serological tests were performed: 1. total IgE (RIST), 2. presence of penicilloyl-specific IgE (RAST), 3. penicilloyl-reactive antibodies using an antiglobulin-haemagglutination-tests. In addition, PHA-induced lymphocyte transformation was studied in 10 patients with exanthems. 38/42 patients developed transient monomorphic morbiliform or scarlatiniform exanthems. 4. exanthems were classified as urticarial or polymorphic. In contrast to the 38 patients, the latter also were positive in the serological tests as it is observed in patients with IgE-mediated penicillin allergy.
538名因各种抗菌治疗指征而入住参与本研究医院的患者，接受了氨苄西林类似物埃比西林的治疗。42名出现皮疹的患者（7.8%）接受了详细的临床和免疫学调查。根据埃比西林的应用形式和剂量以及皮疹的形态和发病时间对皮疹进行评分。进行了多种血清学检测：1. 总IgE（RIST），2. 青霉素酰特异性IgE的存在情况（RAST），3. 使用抗球蛋白血凝试验检测青霉素酰反应性抗体。此外，对10名出疹患者进行了PHA诱导的淋巴细胞转化研究。42名患者中有38名出现了短暂的单形性麻疹样或猩红热样皮疹。4. 皮疹被分类为荨麻疹样或多形性。与这38名患者不同的是，后者在血清学检测中也呈阳性，这在IgE介导的青霉素过敏患者中可以观察到。
