[对β-内酰胺类药物过敏。体内诊断及其与体外试验（淋巴细胞转化和特异性IgE）的相关性（作者译）]

[Allergy to betalactamins. Diagnosis in vivo and correlations with tests in vitro (lymphocyte transformation and specific IgE) (author's transl)].

作者信息

Grosshans E, Hugues L, Samsoen M, Thierry R

出版信息

Ann Dermatol Venereol. 1978 Jun-Jul;105(6-7):609-14.

Abstract

A comparative study of the results of skin tests and tests in vitro (lymphocyte transformation L.T. and R.A.S.T. for specific IgE) in 21 patients allergic to penicillin or penicillin-derivates revealed that tests in vivo are more sensitive and reliable than L.T. and R.A.S.T. This discordance needs future research for more valuable tests in vitro, such as specific histamine-release by leucocytes or determination of IgG4 reagins by R.A.S.T. procedure. A method of diagnosis of betalactamin hypersensitivity by skin tests, including penicilloylpolylysine, benzyl-penicillin, ampicillin and cephalosporin, is suggested; this method was experienced in 21 patients and 23 control subjects and proved to be safe and reproducible.

摘要

一项针对21名对青霉素或青霉素衍生物过敏患者的皮肤试验与体外试验（淋巴细胞转化试验L.T.和针对特异性IgE的放射变应原吸附试验R.A.S.T.）结果的对比研究表明，体内试验比L.T.和R.A.S.T.更敏感、更可靠。这种不一致性需要未来开展更多研究，以寻找更有价值的体外试验，比如白细胞特异性组胺释放试验或通过放射变应原吸附试验程序测定IgG4反应素。本文提出了一种通过皮肤试验诊断β-内酰胺超敏反应的方法，包括使用青霉噻唑聚赖氨酸、苄青霉素、氨苄青霉素和头孢菌素进行试验；该方法在21名患者和23名对照受试者身上进行了验证，结果证明是安全且可重复的。