Zöllner C, Beck C, Mittermayer C
HNO. 1980 Nov;28(11):376-9.
A variety of congenital or acquired diseases may cause macroglossia. We report the case study of a 25 year old patient with Down's Syndrome who developed macroglossia after injury to the tongue from a self-inflicted bite. Conservative therapy for one month through wound revision, antibiotics and antiphlogistics was only successful in controlling infection but failed to prevent the occurrence of a massive macroglossia. This latter problem could only be managed through reconstructive surgery. Histological studies of tissue taken from the tongue revealed the presence of an interstitial edema containing protein, but without evidence for mucopolysaccharides, glycogen or amyloid. A network of dilated blood and lymphatic vessels with partial stenoses caused by organized thrombosis and proliferation of endothelial cells could be observed, suggesting the presence of a congenital lymphangio-hemangioma. However, we believe that these findings were the result of the obliteration of lymphatic and blood vessels through trauma and inflammation to produce the patient's macroglossia.
多种先天性或后天性疾病可能导致巨舌症。我们报告了一例25岁唐氏综合征患者的病例研究，该患者因自伤咬伤舌头后出现巨舌症。通过伤口修复、抗生素和消炎药进行了一个月的保守治疗，仅成功控制了感染，但未能防止出现巨大巨舌症。后一个问题只能通过重建手术解决。对取自舌头的组织进行的组织学研究显示存在含有蛋白质的间质水肿，但没有粘多糖、糖原或淀粉样蛋白的证据。可以观察到由有组织的血栓形成和内皮细胞增殖导致部分狭窄的扩张血管和淋巴管网络，提示存在先天性淋巴管血管瘤。然而，我们认为这些发现是由于创伤和炎症导致淋巴管和血管闭塞，从而产生患者的巨舌症。
