Shaw D M, Tidmarsh S F, Karajgi B M
J Affect Disord. 1980 Dec;2(4):321-5. doi: 10.1016/0165-0327(80)90034-8.
Patients suffering from unipolar illness and anticipating a complex investigation, or the first of a series of ECTs, had lower total tryptophan levels than control subjects under the former circumstances. This suggested a qualitative or quantitative difference in response to stress, associated with a fall in the amino acid level. It was hypothesized that this might selectively decrease synthesis of both protein and 5-HT in serotoninergic neurones.
患有单相情感障碍疾病且预期要接受复杂检查或首次接受一系列电休克治疗的患者，在前一种情况下，其总色氨酸水平低于对照组。这表明对应激的反应在质或量上存在差异，与氨基酸水平下降有关。据推测，这可能会选择性地降低血清素能神经元中蛋白质和5-羟色胺的合成。
