Coupal J J, Kim E E, DeLand F H
J Nucl Med. 1981 Feb;22(2):153-6.
Tc-99m methylene diphosphonate (MDP) was prepared using stannous methylene diphosphonate (ligand) kits of similar formula from either of two manufacturers (A or B), and physiologic saline of either regular dissolved oxygen content (RDO, 6.7 mg O2/l) or low (LDO, 3.8 mg O2/l). A resulting Tc-99m MDP dose was administered to each of 70 patients for bone imaging. The A + RDO combination led to greater film density in the bone image than did the B + RDO (p less than 0.05). However, use of LDO saline to reconstitute B improved bone-image density to equal that from A + RDO. Overall image quality with A + RDO was judged to be superior to that with either B + RDO (p less than 0.05) or B + LDO (p less than 0.01) by an investigator unaware of the particular DO and ligand combination injected. However, neither bone delineation nor soft-tissue radioactivity on images was judged to be different among the four combinations (p greater than or equal to 0.05). There was also no difference in soft-tissue radioactivity among the four combinations as revealed by image densitometry. Under the conditions of this study, the major differences in clinical performance between products A and B were only minimally affected by the O2 content of the saline used for reconstitution.
使用来自两家制造商（A或B）中任何一家的配方相似的亚甲基二膦酸亚锡（配体）试剂盒，以及正常溶解氧含量（RDO，6.7毫克O₂/升）或低溶解氧含量（LDO，3.8毫克O₂/升）的生理盐水，制备锝-99m亚甲基二膦酸盐（MDP）。将所得的锝-99m MDP剂量分别给予70例患者进行骨显像。A + RDO组合在骨图像中产生的胶片密度高于B + RDO组合（p小于0.05）。然而，使用LDO生理盐水复溶B可使骨图像密度提高到与A + RDO组合相当的水平。一位不知道所注射的具体溶解氧和配体组合的研究者判断，A + RDO的总体图像质量优于B + RDO（p小于0.05）或B + LDO（p小于0.01）。然而，在四种组合中，图像上的骨轮廓或软组织放射性均无差异（p大于或等于0.05）。图像密度测定显示，四种组合之间的软组织放射性也没有差异。在本研究条件下，产品A和B在临床性能上的主要差异仅受到用于复溶的生理盐水的氧含量的轻微影响。
