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锝-99m羰基二膦酸、二羟基亚甲基二膦酸和单羟基亚甲基膦酸的亲骨特性：简要通讯

Bone-seeking properties of Tc-99m carbonyl diphosphonic acid, dihydroxy-methylene diphosphonic acid and monohydroxy-methylene phosphoinic acid: concise communication.

作者信息

Wang T S, Fawwaz R A, Johnson L J, Mojdehi G E, Johnson P M

出版信息

J Nucl Med. 1980 Aug;21(8):767-70.

PMID:7400832
Abstract

Carbonyl diphosphonic acid, dihydroxy-methylene diphosphonic acid and monohydroxy-methylene diphosphonic acid were synthesized and labeled with Tc-99m. Their chemical structures were confirmed and their bone-seeking relationships were compared with those of Tc-99m MDP in experimental animals. MKonohydroxy-methylene diphosphonic acid was found to have higher bone affinity and faster blood clearance than MDP, whereas carabonyl diphosphonic acid and dihydroxy-methylene diphosphonic acid demonstrated lower bone affinity and slower blood clearance than MDP.

摘要

合成了羰基二膦酸、二羟基亚甲基二膦酸和单羟基亚甲基二膦酸并用99mTc进行标记。确定了它们的化学结构，并在实验动物中将它们的骨摄取关系与99mTc-MDP的进行了比较。发现单羟基亚甲基二膦酸比MDP具有更高的骨亲和力和更快的血液清除率，而羰基二膦酸和二羟基亚甲基二膦酸的骨亲和力低于MDP，血液清除率也比MDP慢。

相似文献

1
Bone-seeking properties of Tc-99m carbonyl diphosphonic acid, dihydroxy-methylene diphosphonic acid and monohydroxy-methylene phosphoinic acid: concise communication.锝-99m羰基二膦酸、二羟基亚甲基二膦酸和单羟基亚甲基膦酸的亲骨特性：简要通讯
J Nucl Med. 1980 Aug;21(8):767-70.
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A study of the relationship between chemical structure and bone localization of Tc-99m diphosphonic acids: concise communication.锝-99m二膦酸盐的化学结构与骨定位关系的研究：简要通讯
J Nucl Med. 1979 Oct;20(10):1066-70.
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Effects of acute administration of ethane hydroxydiphosphonate (EHDP) on skeletal scintigraphy with technetium-99m methylene diphosphonic acid (Tc-MDP) in the rat.急性给予乙烷羟基二膦酸盐（EHDP）对大鼠用锝-99m亚甲基二膦酸盐（Tc-MDP）进行骨骼闪烁显像的影响。
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Tc-99m HMDP (hydroxymethylene diphosphonate): a radiopharmaceutical for skeletal and acute myocardial infarct imaging. I. Synthesis and distribution in animals.锝-99m 亚甲基二膦酸盐（HMDP）：一种用于骨骼和急性心肌梗死成像的放射性药物。I. 合成及在动物体内的分布
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Synthesis, radiotechnetium labelling, and comparison of biologic behavior of longer-chain analogs of methylene diphosphonate.
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A Bone-Seeking trans-Cyclooctene for Pretargeting and Bioorthogonal Chemistry: A Proof of Concept Study Using Tc- and Lu-Labeled Tetrazines.一种用于预靶向和生物正交化学的骨靶向反式环辛烯：使用锝和镥标记的四嗪的概念验证研究
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Technetium-1,2-dihydroxy-1,2-bis(dihydroxyphosphinyl)ethane (99mTc-DHPE). A promising new skeletal imaging agent.
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