乙醇对小鼠和大鼠早期发育的影响。II. 对植入后早期大鼠胚胎的体外影响。

The effect of ethanol upon early development in mice and rats. II. In vitro effect upon early postimplantation rat embryos.

作者信息

Sandor S, Fazakas-Todea I, Checiu M

出版信息

Morphol Embryol (Bucur). 1980 Oct-Dec;26(4):315-20.

Abstract

The direct effect of ethanol upon in vitro cultured 9.5 day rat embryos was investigated (2, 4, 8 and 10% ethanol added to the culture medium). The main effects recorded were as follows: 1. Significant increase of the number of "dying" embryos (beating heart without yolk sac circulation); 2. No significant increase of mortality; 3. Significant increase of the number of living embryos with deficient blood circulation; 4. Significant retardation of coiling in living embryos with a significant dose-effect relation, when the effects of 20/00 and 80/00 ethanol were compared; 5. Lowering of the mean somite number in living embryos; 6. Various macro- and macroscopical pathological changes (mainly necrotic areas in the central nervous system).

摘要

研究了乙醇对体外培养的9.5天大的大鼠胚胎的直接影响（向培养基中添加2%、4%、8%和10%的乙醇）。记录的主要影响如下：1. “濒死”胚胎（有心跳但无卵黄囊循环）数量显著增加；2. 死亡率无显著增加；3. 血液循环不足的存活胚胎数量显著增加；4. 当比较2%和8%乙醇的作用时，存活胚胎的卷曲明显延迟，且存在显著的剂量效应关系；5. 存活胚胎的平均体节数减少；6. 出现各种大体和肉眼可见的病理变化（主要是中枢神经系统的坏死区域）。