Ilonen J, Herva E, Tiilikainen A, Akerblom H K, Mustonen A, Koivukangas T, Kouvalainen K
Tissue Antigens. 1980 Apr;15(4):381-8. doi: 10.1111/j.1399-0039.1980.tb00199.x.
HLA--A, B and C antigens were determined from 63 cases of juvenile-onset, insulin-dependent diabetes mellitus (IDDM) in northern Finland. There was a very strong association between IDDM and HLA--B8 and B15 antigens in this area where the incidence of IDDM is also high. Relative risks for B8 and B15 were 4.8 and 3.8, respectively. In a small group of subjects typed for HLA--D antigens Dw3 and Dw4 appeared to be stronger risk factors than associated B antigens, whereas Dw2 was almost totally absent in the patients. The effect of combinations of B8 and B15 antigens in unrelated patients and in diabetic families was analyzed. B8, B15 was found in 11 out of 63 unrelated diabetics; however, this did not differ significantly from the expected value. In diabetic families there was no increased rate of intra-HLA recombinations.
对芬兰北部63例青少年起病的胰岛素依赖型糖尿病（IDDM）患者进行了HLA - A、B和C抗原检测。在IDDM发病率较高的该地区，IDDM与HLA - B8和B15抗原之间存在非常强的关联。B8和B15的相对风险分别为4.8和3.8。在一小部分进行了HLA - D抗原分型的受试者中，Dw3和Dw4似乎比相关的B抗原具有更强的风险因素，而患者中几乎完全没有Dw2。分析了B8和B15抗原组合在非亲属患者和糖尿病家族中的作用。63例非亲属糖尿病患者中有11例发现了B8、B15；然而，这与预期值无显著差异。在糖尿病家族中，HLA内部重组率没有增加。
