一种与HLA抗原A9和Bw16相关的胰岛素依赖型糖尿病（IDD）的胰岛细胞抗体阴性形式。
An islet cell antibody negative form of insulin-dependent diabetes mellitus (IDD) associated with HLA antigens A9 and Bw16.
作者信息
Mustonen A, Ilonen J, Akerblom H K, Tiilikainen A
出版信息
Clin Exp Immunol. 1982 Apr;48(1):213-7.
Abstract
One hundred and sixty-six unrelated children and adolescents having growth-onset, insulin-dependent diabetes mellitus (IDD) were studied for pancreatic-cytoplasmic islet cell antibodies (ICA) at various times from the diagnosis of the disease. A strong association between HLA antigens A9 and Bw16 and an absence of ICA early in the course of disease was seen. On the other hand B8/Dw3 or B15/Dw4 antigens were not significantly associated with the occurrence of ICA although both these antigens are greatly increased among pediatric IDD patients in northern Finland. The finding of the association of the HLA antigens A9 and Bw16 with ICA-negativity contributes to the evidence for the heterogeneity in the genetic susceptibility to IDD.
摘要
对166名患有生长型胰岛素依赖型糖尿病（IDD）的非亲属儿童和青少年在疾病诊断后的不同时间进行了胰岛细胞质胰岛细胞抗体（ICA）研究。研究发现，HLA抗原A9和Bw16与疾病早期ICA缺失之间存在强关联。另一方面，尽管在芬兰北部的儿童IDD患者中，B8/Dw3或B15/Dw4抗原的比例大幅增加，但它们与ICA的发生并无显著关联。HLA抗原A9和Bw16与ICA阴性的关联这一发现，为IDD遗传易感性的异质性提供了证据。
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本文引用的文献
1
The genetics of the glucose intolerance disorders.
Am J Med. 1981 Jan;70(1):116-26. doi: 10.1016/0002-9343(81)90418-6.
2
Residual beta-cell function and islet cell antibodies in diabetic children.
Pediatr Res. 1981 Jan;15(1):62-5. doi: 10.1203/00006450-198101000-00015.
3
Genetic patterns in diabetes mellitus.糖尿病的遗传模式。
Hum Pathol. 1980 May;11(3):273-83. doi: 10.1016/s0046-8177(80)80009-8.
4
HLA genetics of insulin-dependent juvenile-onset diabetes mellitus in northern Finland.芬兰北部胰岛素依赖型青少年发病型糖尿病的HLA遗传学
Tissue Antigens. 1980 Apr;15(4):381-8. doi: 10.1111/j.1399-0039.1980.tb00199.x.
5
Complement-fixing islet-cell antibodies before and after onset of insulin-dependent diabetes.胰岛素依赖型糖尿病发病前后的补体结合胰岛细胞抗体。
Lancet. 1980 Oct 11;2(8198):805. doi: 10.1016/s0140-6736(80)90422-5.
6
Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies.伴有自身免疫性多内分泌腺缺陷的糖尿病中的胰岛细胞抗体。
Lancet. 1974 Nov 30;2(7892):1279-83. doi: 10.1016/s0140-6736(74)90140-8.
7
HL-A antigens and diabetes mellitus.组织相容性白细胞抗原与糖尿病
Lancet. 1974 Oct 12;2(7885):864-6. doi: 10.1016/s0140-6736(74)91201-x.
8
Juvenile diabetes mellitus: possibility of prevention.青少年糖尿病：预防的可能性。
Arch Dis Child. 1979 Aug;54(8):569-80. doi: 10.1136/adc.54.8.569.
9
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