Behm E
Z Gesamte Inn Med. 1980 Aug 1;35(15):Suppl 41-3.
The tendency to recognize immune complexes already before their deposition in the tissue led in the seventies to the development of numerous methods of estimation for immune complexes in the serum and to the proof of these complexes in many diseases. The author enters these methods and their problems, the results got up to now for renal diseases, i. e. above all for glomerulonephritides, are cited in form of theses. Among others belong to this the establishments that the proof of circulating immune complexes cannot contribute to the diagnosis, but to the control of the activity of the diseases and of the therapeutic effect. Recently, research concerning immune complexes yielded remarkable results as to their role as regulating factors of the unspecific as well as of the specific defense mechanisms of the organism. This promises that further clarifications on etiology and genesis particularly of diseases of the immune complex type are to be expected, among them also for glomerulonephritides.
早在免疫复合物沉积于组织之前就能够识别它们的这种趋势，在20世纪70年代催生了多种血清中免疫复合物的检测方法，并证实了这些复合物在许多疾病中的存在。作者阐述了这些方法及其存在的问题，截至目前针对肾脏疾病（即主要是肾小球肾炎）所取得的结果以论点的形式被引用。其中包括这样的定论，即循环免疫复合物的检测无助于诊断，但有助于疾病活动度及治疗效果的监测。最近，关于免疫复合物的研究在其作为机体非特异性及特异性防御机制调节因子的作用方面取得了显著成果。这预示着有望对特别是免疫复合物型疾病的病因及发病机制有进一步的阐明，其中也包括肾小球肾炎。
