Lohninger A, Krieglsteiner P, Riedl W, Erhardt W, Blümel G
Z Geburtshilfe Perinatol. 1978 Feb;182(1):29-37.
Carnitine is a body-owned Betaine which is wide-spread in living nature in the form of a physiologic metabolit. On account of its central metabolic function, Carnitine has various effects in the intermediary metabolism. Toxicity of Carnitine is very low. DL-Carnitine hydrochloride (30 mg/kg body weight) was injected into 25 gravid Wistar rats and 24 gravid rabbits, 4 days before the Cesarean section. Compared to the group of controls, the group treated with Bromhexine metabolit VIII, as well as to the group treated with Betamethason, significantly higher values with regard to the content of total phospholipids, lecithine and palmitic acid could be found in the fetal rat lungs. Effects of Carnitine on the phospholipid metabolism are discussed.
肉碱是一种机体自身含有的甜菜碱，以生理代谢物的形式广泛存在于生物界。由于其核心代谢功能，肉碱在中间代谢中具有多种作用。肉碱的毒性非常低。在剖宫产术前4天，将盐酸DL-肉碱（30毫克/千克体重）注射到25只妊娠的Wistar大鼠和24只妊娠的兔子体内。与对照组相比，用溴己新代谢物VIII处理的组以及用倍他米松处理的组，在胎鼠肺中总磷脂、卵磷脂和棕榈酸的含量方面发现显著更高的值。讨论了肉碱对磷脂代谢的影响。
