Esteban A, Mateo D, Giménez-Roldán S
J Neurol Neurosurg Psychiatry. 1981 Jan;44(1):43-8. doi: 10.1136/jnnp.44.1.43.
The R2 response on the blink reflex was found to be abnormal in seven out of 17 Huntington's disease descendants. Such abnormalities were present in four untreated subjects and in three further subjects after administration of a single oral dose of levodopa-carbidopa. An increase in latency and differential latency (four cases), or in a single one of these parameters (three cases) were the abnormalities found, resembling findings in four incipient cases detected during routine family surveys. Continuous administration of levodopa-carbidopa over a 10-20 day period did not induce new characteristics in the blink reflex, nor increase those detected previously, and no case developed chorea. We suggest that the analysis of the blink reflex after a single oral levodopa-carbidopa dosage could provide an objective and quantifiable method for the detection of individuals at risk for Huntington's disease.
在17名亨廷顿舞蹈症患者后代中，有7人被发现瞬目反射的R2反应异常。4名未接受治疗的患者以及另外3名单次口服左旋多巴-卡比多巴后的患者存在此类异常情况。发现的异常包括潜伏期和差值潜伏期增加（4例），或其中单个参数增加（3例），这与在常规家庭调查中检测出的4例初期病例的结果相似。在10 - 20天内持续服用左旋多巴-卡比多巴并未在瞬目反射中诱发新特征，也未增加之前检测到的异常情况，且无一例出现舞蹈症。我们认为，单次口服左旋多巴-卡比多巴后对瞬目反射进行分析，可为检测有患亨廷顿舞蹈症风险的个体提供一种客观且可量化的方法。
