Nakamura S, Yoneda T, Takai A
Jpn J Antibiot. 1980 Oct;33(10):1019-27.
Muscular injury caused by cefoperazone (CPZ) was compared with that of cefazolin (CEZ), cephaloridine (CER) or cephalothin (CET) in adult and juvenile male rabbits. These drugs were dissolved by the way of clinical use and were injected singly into the muscular vastus lateralis. Then, the degree of muscular injury at the time of 48 hours and 7 days after the injection was judged from muscle ratio, gross local observation and histological observations. The degree of muscular injury caused by these drugs was compared also with that of saline 075% or 6% acetic acid. The following results were obtained: There was no difference among CPZ, CEZ and CER on the degree of muscular injury and these changes were almost equal to those of 0.75% acetic acid, however severer than that of saline. While, muscular injury caused by CET was severer than that of CPZ, CEZ, CER or 0.75% acetic acid, but milder than 6% acetic acid. The inflammatory reaction against these drugs was almost similar in adult and juvenile rabbits.
在成年和幼年雄性兔子中，比较了头孢哌酮（CPZ）与头孢唑林（CEZ）、头孢噻啶（CER）或头孢噻吩（CET）所致的肌肉损伤。这些药物按临床使用方式溶解后，单独注射到股外侧肌中。然后，根据肌肉比率、大体局部观察和组织学观察，判断注射后48小时和7天时的肌肉损伤程度。还将这些药物所致的肌肉损伤程度与0.75%生理盐水或6%乙酸所致的损伤程度进行了比较。得到以下结果：CPZ、CEZ和CER在肌肉损伤程度上没有差异，这些变化几乎与0.75%乙酸所致的变化相同，但比生理盐水所致的变化更严重。而CET所致的肌肉损伤比CPZ、CEZ、CER或0.75%乙酸所致的更严重，但比6%乙酸所致的更轻。成年和幼年兔子对这些药物的炎症反应几乎相似。
