Nakada H, Takimoto Y, Kawamura Y, Takai A
Jpn J Antibiot. 1982 Sep;35(9):2155-8.
The local irritation effect of T-1982 after the intramuscular injection into the musculus vastus lateralis was examined in rabbits. T-1982 was dissolved by the way of clinical use and was injected singly into the musculus vastus lateralis. Then the degree of muscular injury at the time of 2 days and 7 days after the injection was judged from muscle weight ratio, gross local observation and histological observation. The degree of muscular injury caused by T-1982 was compared with that of saline, 0.75% acetic acid and 6% acetic acid. On the degree of muscular injury of T-1982 was almost equal to that of 0.75% acetic acid, but milder than 6% acetic acid. From these, it was concluded that the local irritation effect of T-1982 was grade 3.
在兔的股外侧肌进行肌内注射后，对T - 1982的局部刺激作用进行了研究。T - 1982按临床使用方法溶解，并单独注射到股外侧肌中。然后根据肌肉重量比、大体局部观察和组织学观察，判断注射后2天和7天时的肌肉损伤程度。将T - 1982引起的肌肉损伤程度与生理盐水、0.75%乙酸和6%乙酸的损伤程度进行比较。T - 1982的肌肉损伤程度几乎与0.75%乙酸的相等，但比6%乙酸的轻。由此得出结论，T - 1982的局部刺激作用为3级。
