Phung N D, Davidson P T
Ann Allergy. 1981 Apr;46(4):204-7.
Immunologic studies were done in a patient with common variable hypogammaglobulinemia, bronchiectasis and M. avium intracellulare pulmonary infection. Adherent cells from the patient were found to suppress the proliferative response of normal control cells to PPD antigen. The suppression seemed to be mediated by prostaglandin as it was reversed by indomethacin. Increased suppressor cell activity may play an important role in the pathogenesis of Mycobacterium avium-intracellulare infection by permitting the transformation of a status of colonization by the organism in pre-existing pulmonary conditions into an invasive, progressive disease.
对一名患有常见可变型低丙种球蛋白血症、支气管扩张和鸟分枝杆菌胞内肺部感染的患者进行了免疫学研究。发现该患者的黏附细胞可抑制正常对照细胞对结核菌素纯蛋白衍生物（PPD）抗原的增殖反应。这种抑制作用似乎是由前列腺素介导的，因为吲哚美辛可逆转该抑制作用。抑制细胞活性增加可能在鸟分枝杆菌胞内感染的发病机制中起重要作用，它可使该病原体在先前存在的肺部疾病中由定植状态转变为侵袭性、进行性疾病。
